FROM EXPERIMENT TO MEDICINAL SUBSTANCES



Long-term investigations performed by the research team of the Institute resulted in creating a new class of geroprotectors ? peptide bioregulators. The administration of peptide bioregulators enables effective prevention of premature ageing and therapy of age-related diseases.

Researchers of the Institute are the inventors of a number of medicinal and prophylactic pharmaceutical substances, which have been adopted by the Russian Ministry of Public Health and are presently under serial production:
  • 6 geroprotective medications (Thymalin, Thymogen, Epithalamin, Prostatilen, Cortexin, Retinalamin);
  • 30 types of cell metabolism bioregulators,
  • 5 highly efficient synthesized peptides (Vilon, Epitalon, Cortagen, Livagen, Prostamax), which largely have no analogues in other countries.
There were chemically synthesized  over 100 biologically active peptides which revealed the ability to hold back the process of ageing.

According to the concept of peptide bioregulation, a theory of endogenous peptide bioregulators? involvement in the maintenance of structural and functional homeostasis of cell populations, containing and producing these factors, was formulated. These endogenous peptides became commonly known as ?Cytomedins?.

Cytomedins control gene expression and protein synthesis, thus preventing age-related accumulation of quantitative structural and functional alterations, which are the markers of transition of a biological system from the norm to the pathology. Disordered peptide bioregulation reduces organism resistance to external and internal destabilizing factors, serving a cause of premature ageing.
A long record of peptide bioregulators application in the health service  has demonstrated their high effectiveness in combating various disease and pathologies, including those refractory to other medicines.

The researchers developed a new technology for creating biologically active food supplements (parapharmaceuticals), based on peptide complexes isolated from animal organs and tissues. A new group of parapharmaceuticals has received a name of ?Cytomaxes?. Biologically active food supplements are produced in the form of tablets and capsules. Cytomaxes exert a regulatory effect on the cellular level and are used for improving the organism resistance to the impact of adverse environmental, climatic, occupational and other factors, as well as during the rehabilitation period after surgeries, traumas, diseases; in case of malnutrition, high physical loads; for the purpose of maintaining the functions of the main organism systems in old and very old persons in order to reduce the risk of disease occurrence.


CYTOMAXES ? NATURAL PEPTIDE COMPLEXES (PARAPHARMACEUTICALS)
CERLUTEN?
brain bioregulator
Correction of central nervous system functions
THYREOGEN?
thyroid gland bioregulator
Correction of endocrine system functions
VENTFORT?
vessels bioregulator
Correction of cardiovascular system functions
SIGUMIR?
cartilaginous tissue bioregulator
Correction of locomotor apparatus functions
SVETINORM?
liver bioregulator
Correction of digestive system functions
SUPREFORT?
pancreas bioregulator
VLADONIX?
thymus bioregulator
Correction of immune system functions

One of the recent achievements of the Institute is a technology for synthesizing from amino acids a new group of bioregulators ? ?Cytogens?. Cytogens are peptide pharmaceuticals and parapharmaceuticals, which exert a pronounced regulatory effect on protein biosynthesis in the cells.


CYTOGENS ? SYNTHESIZED PEPTIDES (PHARMACEUTICALS AND PARAPHARMACEUTICALS)
PINEALON?
synthesized brain peptide
Correction of central nervous system functions
VESUGEN?
CARDIOGEN?
synthesized vessels peptide
synthesized cardiac peptide
Correction of cardiovascular system functions
CARTALAX?
synthesized cartilaginous tissue peptide
Correction of locomotor apparatus functions
OVAGEN?
synthesized liver peptide
Correction of liver functions
CHONLUTEN?
BRONCHOGEN?
synthesized lungs peptide
synthesized bronchial peptide
Correction of respiratory system functions
PANCRAGEN?
synthesized pancreas peptide
Correction of carbohydrate metabolism
CRYSTAGEN?
synthesized thymus peptide
Correction of immune system functions
TESTAGEN?
synthesized testis peptide
Correction of male sexual functions

On the basis of the natural peptide complexes, the Institute researchers developed a new class of medicinal substances ? ?Peptomaxes?. These medicinal substances significantly improve the effectiveness of standard methods of organism rehabilitation after the impact of different adverse factors (traumas, irradiation, intoxication, infection, psychoemotional stress). They are used for preventing and correcting different conditions, which are accompanied by disordered organism resistance and some physiological functions, as well as in age-related pathology.

PEPTOMAXES ? NATURAL POLYPEPTIDE COMPLEXES (PHARMACEUTICALS)
BRAIN EXTRACT
Correction of central nervous system functions
PINEAL GLAND EXTRACT
THYROID GLAND EXTRACT
Correction of endocrine system functions
VESSELS EXTRACT
Correction of cardiovascular system functions
CARTILAGES EXTRACT
Correction of locomotor apparatus functions
LIVER EXTRACT
Correction of digestive system functions
KIDNEYS EXTRACT
TESTIS EXTRACT
OVARIES EXTRACT
URNARY BLADDER EXTRACT
Correction of urogenital system functions
RETINAL EXTRACT
Correction of visual functions